Exploring the Na+/K+-ATPase:Src kinase complex

Exploring the diversity of complex metabolic networks

MOTIVATION Metabolism, the network of chemical reactions that make life possible, is one of the most complex processes in nature. We describe here the development of a computational approach for the identification of every possible biochemical reaction from a given set of enzyme reaction rules that allows the de novo synthesis of metabolic pathways composed of these reactions, and the evaluatio...

Ultracold Fermionic Feshbach Molecules of NaK

We report on the formation of ultracold fermionic Feshbach molecules of NaK, the first fermionic molecule that is chemically stable in its ground state. The lifetime of the nearly degenerate molecular gas exceeds 100 ms in the vicinity of the Feshbach resonance. The measured dependence of the molecular binding energy on the magnetic field demonstrates the open-channel character of the molecules...

Exploring kinase cosubstrate promiscuity: monitoring kinase activity through dansylation.

Protein kinase Cdc15 activates the Dbf2-Mob1 kinase complex.

Exit from mitosis in budding yeast requires inactivation of cyclin-dependent kinases through mechanisms triggered by the protein phosphatase Cdc14. Cdc14 activity, in turn, is regulated by a group of proteins, the mitotic exit network (MEN), which includes Lte1, Tem1, Cdc5, Cdc15, Dbf2/Dbf20, and Mob1. The direct biochemical interactions between the components of the MEN remain largely unresolv...

-Dependent Activation of the mTORC2 Kinase Complex